| Program | Network | Unique Viewers (000) |
| Lost | ABC.com | 1,425 |
| Saturday Night Live | NBC.com | 1,111 |
| Grey’s Anatomy | ABC.com | 879 |
| Desperate Housewives | ABC.com | 723 |
| Heroes | NBC.com | 685 |
| Ugly Betty | ABC.com | 631 |
| Samantha Who? | ABC.com | 560 |
| Scrubs | ABC.com | 519 |
| Survivor | CBS Television | 496 |
| True Beauty | ABC.com | 462 |
| Source: Nielsen | ||