| Rank | Title | Distributor | Total US$ | Open Date |
| 1 | THE DARK KNIGHT | Warner Bros. | 530,540,885 | 07/18/2008 |
| 2 | IRON MAN | Paramount | 318,313,199 | 05/02/2008 |
| 3 | INDIANA JONES AND THE KINGDOM OF THE CRYSTAL SKULL | Paramount | 317,023,851 | 05/22/2008 |
| 4 | HANCOCK | Sony | 227,946,274 | 07/02/2008 |
| 5 | WALL-E | Disney | 223,704,223 | 06/27/2008 |
| 6 | KUNG FU PANDA | Paramount | 215,434,591 | 06/06/2008 |
| 7 | MADAGASCAR: ESCAPE 2 AFRICA | Paramount | 165,653,852 | 11/07/2008 |
| 8 | DR. SEUSS’ HORTON HEARS A WHO | Fox | 154,529,439 | 03/14/2008 |
| 9 | SEX AND THE CITY | Warner Bros. | 152,647,258 | 05/30/2008 |
| 10 | QUANTUM OF SOLACE | Sony | 151,620,134 | 11/14/2008 |
| Source: Nielsen | ||||