| Rank | Song | Artist | Total Listeners | |
| 1 | No One | Alicia Keys | 3,084,014,000 | |
| 2 | Low | Flo Rida Featuring T-Pain | 3,025,670,000 | |
| 3 | Bleeding Love | Leona Lewis | 2,754,498,000 | |
| 4 | Apologize | Timbaland Featuring OneRepublic | 2,508,246,000 | |
| 5 | Lollipop | Lil Wayne Featuring Static Major | 2,365,270,000 | |
| 6 | With You | Chris Brown | 2,348,062,000 | |
| 7 | Love in this Club | Usher Featuring Young Jeezy | 2,280,490,000 | |
| 8 | No Air | Jordin Sparks Duet With Chris Brown | 2,170,133,000 | |
| 9 | Sexy Can I | Ray J & Yung Berg | 1,926,995,000 | |
| 10 | Take A Bow | Rihanna | 1,920,855,000 | |
| Source: Nielsen | ||||